![]() Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment. Zhao X, Pei D, Yang Y, Xu K, Yu J, Zhang Y, Zhang Q, He G, Zhang Y, Li A, Cheng Y, Chen X. Recent advances in biomaterials for the treatment of diabetic foot ulcers. Antioxidative and angiogenesis-promoting effects of tetrahedral framework nucleic acids in diabetic wound healing with activation of the Akt/Nrf2/HO-1 pathway. Lin S, Zhang Q, Li S, Zhang T, Wang L, Qin X, Zhang M, Shi S, Cai X. A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes. Wei S, Xu P, Yao Z, Cui X, Lei X, Li L, Dong Y, Zhu W, Guo R, Cheng B. Improving chronic diabetic wound healing through an injectable and self-healing hydrogel with platelet-rich plasma release. Qian Z, Wang H, Bai Y, Wang Y, Tao L, Wei Y, Fan Y, Guo X, Liu H. These results indicate that nanofiber/hydrogel core-shell scaffolds with 3D multilayer patterned structures could provide a new strategy for facilitating chronic wound healing.Īngiogenesis Cell infiltration Diabetic wound healing Hydrogel/nanofiber scaffolds Multilayer patterned structure. As a result, the healing of diabetic wounds was accelerated with enhanced angiogenesis, granulation tissue formation, and collagen deposition. The in vivo results further demonstrated that the 3D-PT-P/GM scaffolds could not only effectively absorb exudate and provide a moist environment for the wound sites, but also significantly promote the formation of a 3D network of capillaries. The in vitro studies showed that the 3D-PT-P/GM scaffolds could significantly promote cell adhesion, proliferation, infiltration and migration throughout the scaffolds, and the expression of cellular communication protein-related genes, as well as angiogenesis-related genes in the same group, was remarkably upregulated. ![]() The results showed that the porosity, water retention time and water vapor permeability of the 3D-PT-P/GM scaffolds increased to 1.6 times, 21 times, and 1.9 times than that of the two-dimensional (2D) PDLLA nanofibrous scaffolds, respectively. Another proposed polymer in tissue engineering is poly (1, 8-octane diol citrate), a biodegradable, and biocompatible polyester with a similar structure to the PGS 32. The nanofibers in the scaffold exhibited distinct core-shell structures with Gelatin methacryloyl (GelMA) hydrogel as the shell and Poly (D, L-lactic acid) (PDLLA) as the core. The coreshell structure showed higher hydrophilicity compared to the PGS/PCL scaffold, and supported cell attachment, proliferation, and differentiation very well. The results showed that the 3D-PT-P/GM scaffolds possessed multilayered structure with interlayer spacing of about 15-80 μm, and the hexagonal micropatterned structures were uniformly distributed on the surface of each layer. Herein, a nanofiber/hydrogel core-shell scaffold with three-dimensional (3D) multilayer patterned structure (3D-PT-P/GM) was introduced for promoting diabetic wound healing with improved angiogenesis. Impaired angiogenesis is one of the predominant reasons for non-healing diabetic wounds.
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